Precision Starts with Methylation

Track the Body’s Earliest Changes with Accuracy

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Methylation is a promising approach

DNA methylation is a key epigenetic modification that plays a crucial role in tumor development.Aberrant changes in methylation patterns can serve as early signals of cancer, including precancerous lesions, making it a promising biomarker for ultra-early detection.

How methylation works​

When tumor cells release circulating tumor DNA (ctDNA) into the bloodstream after cell death, they carry genetic and epigenetic changes. By capturing trace amounts of ctDNA and identifying specific methylation patterns, we can detect tumors earlier and more accurately than with traditional methods. This approach off ers a more precise view into the tumor’s development and progression.

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Reference
[1] Rajabi H , Tagde A , Alam M , et al. DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells[J]. Oncogene, 2016.
[2]Wan, J.C.M. et al. (2017) Liquid biopsies come of age: to-wards implementation of circulating tumour DNA. Nat.Rev. Cancer 17, 223–238.
[3]Gao Y, et al. Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer. Clin Transl Med. 2022 Aug;12(8):e1014.