Precision Starts with Methylation
Track the Body’s Earliest Changes with Accuracy
Methylation is a promising approach
DNA methylation is a key epigenetic modification that plays a crucial role in tumor development.Aberrant changes in methylation patterns can serve as early signals of cancer, including precancerous lesions, making it a promising biomarker for ultra-early detection.
How methylation works
When tumor cells release circulating tumor DNA (ctDNA) into the bloodstream after cell death, they carry genetic and epigenetic changes. By capturing trace amounts of ctDNA and identifying specific methylation patterns, we can detect tumors earlier and more accurately than with traditional methods. This approach off ers a more precise view into the tumor’s development and progression.
Reference
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[2]Wan, J.C.M. et al. (2017) Liquid biopsies come of age: to-wards implementation of circulating tumour DNA. Nat.Rev. Cancer 17, 223–238.
[3]Gao Y, et al. Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer. Clin Transl Med. 2022 Aug;12(8):e1014.
